Progranulin Contributes to Alzheimer’s Disease and Frontotemporal Dementia

Progranulin Contributes to Alzheimer’s Disease and Frontotemporal Dementia
Alzheimer's proteinAnother protein was recently identified as being involved in Alzheimer's disease by researchers at the Gladstone Institutes in California. Progranulin, a protein in the brain, can lead to amyloid-beta plaque formation when its levels are depleted. "This is the first study providing evidence for a protective role of progranulin in Alzheimer's disease," said S. Sakura Minami, PhD, first author of the article describing the research, in a news release from Gladstone. "Prior research had shown a link between Alzheimer's and progranulin, but the nature of the association was unclear. Our study demonstrates that progranulin deficiency may promote Alzheimer's disease, with decreased levels rendering the brain vulnerable to amyloid-beta toxicity." To investigate the prior finding that progranulin is elevated in regions of plaque deposits in the brain and test the theory that progranulin is secreted in an attempt to counteract neurodegeneration, the team at Gladstone studied mouse models of Alzheimer's disease. Described in "Progranulin Protects Against Amyloid Beta Deposition and Toxicity in Alzheimer
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