Researchers Using Natural Compound to ‘Beet’ Alzheimer’s Progression

Researchers Using Natural Compound to ‘Beet’ Alzheimer’s Progression
Betanin, the compound that gives beets their distinctive red color, can help slow the accumulation of misfolded proteins in the brain, a process that is associated with Alzheimer’s disease. The study, “Beeting” Alzheimer’s: Inhibition of Cu2+-β-amyloid mediated oxidation and peroxidation by betanin from sugar beets,” was a poster presentation at the 255th National Meeting & Exposition of the American Chemical Society (ACS) held recently in New Orleans. For decades the main suspect behind Alzheimer’s disease has been beta-amyloid, a protein fragment that accumulates in the brain and disrupts communication between nerve cells. Beta-amyloid has been shown to attach itself to these metals, causing beta-amyloid peptides to misfold and bind together in clumps, promoting inflammation and oxidation in neighboring nerve cells and eventually killing them. Preventing copper from reacting with beta-amyloid potentially could protect the brain from Alzheimer’s promoting mechanisms. University of South Florida (Tampa, Florida) researchers tested if betanin — a beet compound used in commercial dyes that has high affinity for metals — could block copper reactions with beta-amyloid. The team found that when copper and beta-amyloid bound together they are extremely reactive and were likely to support damaging oxidative reactions. In contrast, upon betanin's presence, the reactivity of
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One comment

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