Sleep Deprivation Leads to Accumulation of Protein Fragment Associated With Alzheimer’s

Sleep Deprivation Leads to Accumulation of Protein Fragment Associated With Alzheimer’s
Sleep deprivation in healthy people leads to the accumulation of a protein fragment associated with abnormalities in brain function and Alzheimer's disease. The study, "β-Amyloid accumulation in the human brain after one night of sleep deprivation," published in the Proceedings of the National Academy of Sciences of the United States of America, assessed the effect of one-night sleep deprivation on the accumulation of β-amyloid in the brains of a group of healthy participants. One of the hallmarks of Alzheimer’s disease is the formation of protein plaques and tangles between nerve cells. These are made of so-called beta-amyloid fragments that stick together and accumulate between nerve cells, disrupting their function. Previous research in animal models has shown that sleep restriction can lead to the build-up of beta-amyloid in animals' brains. However, not much is known about the impact of sleep deprivation on β-amyloid burden in the human brain. The study involved 20 healthy individuals whose 22 to 72 years old (average 39.8 years). There was an  equal number of women and men. Beta-amyloid levels were measured using a specific radioactive material that can the be quantified using an imaging technique known as positron emission tomography (PET). These measurements were performed after the individuals
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