ProMIS Working to Move Antibody Treatment for Alzheimer’s into Clinical Trials

ProMIS Working to Move Antibody Treatment for Alzheimer’s into Clinical Trials
ProMIS Neurosciences announced plans to initiate the development of its lead antibody candidate, PMN310, as a potential treatment for Alzheimer's disease. The investigational therapy is expected to enter clinical Phase 1 trials in 2019. PMN310 is a humanized antibody that attacks only toxic forms of the amyloid beta protein linked to Alzheimer's, not its normal forms. Preclinical studies involving both human brain cells in a lab and mice have shown that researchers should be able to increase doses of PMN310 in clinical trials without harming patients, a possibility that’s unlikely in human studies of other therapies. Namely, scientists at ProMIS compared PMN310’s performance with that of other antibodies targeting amyloid beta, the company reported earlier this year. They included Eli Lilly’s solanezumab, Johnson & Johnson and Pfizer’s bapineuzumab, and Biogen’s aducanumab. (Bapineuzumab’s production has since been discontinued.) Selexis will manufacture the investigational treatment using its proprietary Selexis SUREtechnology Platform, a technology that it says will ensure a fast, stable and cost-effective production of antibodies generated in the lab using synthetic genes. According to Selexis, this platform improves the way that mammalian cells are used in the discovery, development, and manufacturing of any
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