Iqra Mumal, MSc,  —

Iron dysregulation in the brains of patients with early onset of Alzheimer’s disease (EOfAD) plays a central role in disease development and progression, according to a new theory. The study, “Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease,” was published in…

A rat model genetically engineered to express high levels of two genes can help researchers learn more about the disease mechanisms that lead to Alzheimer’s disease, a new study shows. The study, “Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model…

Bryostatin, Neurotrope Bioscience’s investigational therapy, was associated with improved cognition in advanced Alzheimer’s disease patients in post-hoc (after-the-fact) analysis of a Phase 2 trial. Results from this study were presented at the Sachs’ Neuroscience Innovation Forum on Jan. 7 in San Francisco, California. Bryostatin-1 is a compound known as…

Takeda Pharmaceutical Company and Zinfandel Pharmaceuticals have brought an early end to a Phase 3 clinical trial after their Alzheimer’s therapy pioglitazone failed to prevent the development of mild cognitive impairment. The decision came less than a year after the partners completed enrollment in the TOMMORROW trial (NCT01931566). An interim analysis…

An approved treatment for diabetes may help people with Alzheimer’s, a study reports. The research, “Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer’s disease,” was published in the journal Brain Research. Many scientists have tried without success to develop Alzheimer’s…

The pharmaceutical company Cortexyme announced that the first group of participants has been dosed in the Phase 1 clinical trial of its lead compound, COR388, for the treatment of Alzheimer’s disease. Because no new successful developments have emerged in Alzheimer’s therapeutics in the last 15 years, researchers have been trying…

Trace levels of lithium in drinking water reduce Alzheimer’s death rates in addition to two risk factors for the disease — obesity and Type 2 diabetes, according to a study. The Canadian study dealt with lithium in Texas’s drinking water. Researchers published their work in the Journal of Alzheimer’s…

Researchers found that the combination of titanate, a nanoparticle that can penetrate the brain-blood barrier, and cerebrolysin, used in some parts of the world to treat problems with cognition, had superior neuroprotective effects in an animal model of Alzheimer’s disease than cerebrolysin alone. The study, “Co-Administration of TiO2 Nanowired…

Doctors tend to miss Alzheimer’s diagnosis in psychotic patients more likely than than non-psychotic ones, according to new research by Canada’s University of Toronto. The study, “Determining the impact of psychosis on rates of false-positive and false-negative diagnosis in Alzheimer’s disease,” appeared in the journal Alzheimer’s & Dementia:…

Cognition Therapeutics’ lead drug candidate for mild-to-moderate Alzheimer’s disease (AD), CT1812, was shown to be well-tolerated and to lower brain levels of proteins involved in the disease, the company reports. These results, part of a Phase 1b/2a clinical trial, were given in an oral presentation at the recent 10th…