One of the hallmarks of Alzheimer’s disease is the formation of protein plaques and tangles between nerve cells. These are made of so-called beta-amyloid fragments that stick together and accumulate between nerve cells, disrupting their function.

These beta-amyloid plaques are the focus of many experimental treatments that researchers are currently developing. Below is a list of the experimental treatments targeting beta-amyloid plaques. More information about each potential treatment is available by clicking on the name of the compound.

ABvac40

ABvac40 is an active vaccine being developed by Araclon Biotech. It consists of a fragment of beta-amyloid protein called beta-amyloid 40. It is designed to elicit an immune response against beta-amyloid plaques.

ACI-24

ACI-24 is a liposome vaccine, being developed by AC Immune. It is based on a fragment of beta-amyloid protein called Aβ-15. It is designed to elicit an antibody response against aggregated beta-amyloid peptides.

Aducanumab

Aducanumab (BIIB037) is a monoclonal antibody being developed by Biogen against aggregated forms of beta-amyloid.

ALZT-OP1

ALZT-OP1, being developed by AZ Therapies, is designed to block beta-amyloid aggregation. It is a combination regimen of two treatments already approved by the U.S. Food and Drug Administration (FDA): cromolyn (designated as ALZT-OP1a) and ibuprofen (designated as ALZT OP1b). It is currently being investigated in a Phase 3 clinical trial (NCT02547818) across the U.S., Australia, and Europe.

BAN2401

BAN2401 is a monoclonal antibody being co-developed by Eisai and Biogen Idec. It specifically binds to large beta-amyloid protofibrils (structures that precede the formation of plaques) and likely leads to their clearance. It is currently being investigated in a Phase 2 clinical trial (NCT01767311).

CAD106

CAD 106 is an investigational, vaccine-based therapy being developed by Novartis. It consists of multiple copies of beta-amyloid 1-6 peptide coupled to a virus-like particle. It elicits a strong immune response while avoiding inflammatory T-cell activation. It is currently being investigated in a Phase2/3 clinical trial (NCT02565511) across the U.S., Canada, and Europe.

CNP520

CNP520, developed by Novartis, is an inhibitor of an enzyme called BACE-1 (or β-secretase) that cleaves APP protein into a fragment that gives rise to beta-amyloid peptide. CNP520-mediated BACE-1 inhibition prevents Aβ formation and limits beta-amyloid deposits. The treatment is currently being investigated in a Phase 2/3 clinical trial (NCT03131453) across the world.

Crenezumab

Crenezumab is an investigational monoclonal antibody developed by AC immune, but now licensed to Genentech. It binds to Aβ peptides that form amyloid plaques in patients with Alzheimer’s disease.

CT1812

CT1812, developed by Cognition Therapeutics, is a small molecule that penetrates the brain and displaces toxic Aβ oligomers from neuronal receptors, allowing nerve cell communication to be restored.

Elenbecestat

Elenbecestat is an oral inhibitor of BACE-1 enzyme. It is being jointly developed by Eisai and Biogen.

Gantenerumab

Gantenerumab is an antibody-based therapy being developed by Roche and Morphosys. It targets Aβ peptides and is designed to dissolve beta-amyloid plaques.

JNJ-54861911

JNJ-54861911, developed by Jannsen Research and Development, is an inhibitor of BACE-1 enzyme. It is currently being investigated in a Phase 2/3 clinical trial (NCT02569398) across the world.

Lasabecestat – LY3314814 

Formerly known as AZD3293, Lasabecestat or LY3314814 is an inhibitor of the BACE1 enzyme that cleaves APP. The cleaved protein fragments stick together and form beta-amyloid plaques in Alzheimer’s. It is being developed by Eli Lilly and Company. 

Lu AF20513

Lu AF20513 is an active vaccine being developed by Lundbeck. It consists of a fragment of Aβ peptide and sequences of tetanus toxin. It is designed to rouse the weak immune system of elderly populations. It is currently being investigated in a Phase 1 clinical trial (NCT02388152) in Europe.

LY3002813

LY3002813 is a monoclonal antibody being developed by Eli Lilly and Company. It targets Aβ aggregated in amyloid plaques. It is currently being investigated in a Phase 1 clinical trial (NCT02624778) in the U.S. and Japan.

LY3202626

LY3202626, developed by Eli Lilly and Company, is an inhibitor of BACE-1 that interferes with the production of beta-amyloid plaques. It is currently being investigated in a Phase 2 clinical trial (NCT02791191) across the world.

Neflamapimod

Neflamapimod is an investigational treatment being developed by EIP Pharma LLC. It specifically inhibits a protein called p38α MAPK (mitogen-activated serine/threonine protein kinase), which plays a major role in Alzheimer’s disease-associated inflammation and impairment of synapses — the points of communication between two neurons — caused by beta-amyloid plaques.

PQ912

PQ912, developed by Probiodrug, is a small molecule inhibitor of an enzyme called glutaminyl cyclase (QC), which gives rise to modified Aβ peptides that form amyloid plaques.

Leukine (sargramostim)

Leukine is a synthetic form of granulocyte-macrophage colony-stimulating factor that stimulates the immune system. It is already approved for several types of leukemia. It is currently being studied at the University of Colorado for the treatment of Alzheimer’s disease to reduce the accumulation of beta-amyloid.

Solanezumab – LY2062430

Solanezumab is an antibody against amyloid-beta being deeloped by Eli Lilly and Company.

Thalidomide

Thalidomide is a molecule able to cross the blood-brain barrier and inhibit the release of tumor necrosis factor-alpha (TNF-α), which activates BACE-1.

UB 311

UB 311 is a peptide vaccine being developed by United Neuroscience. It is designed to stimulate an immune response against aggregated Aβ peptides.

 

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