Tau Protein Turns Toxic and Clusters Under Chronic Cell Stress, Study Finds

Tau Protein Turns Toxic and Clusters Under Chronic Cell Stress, Study Finds
A new study reveals how tau protein drives the formation of stress granules, intended to allow neurons to adapt to stressful conditions, like an injury, during brief periods of time. Findings in the journal Cell Reports show that if stress persists, the tau-stress granule complex does so as well, clustering into the toxic aggregates that promote neurodegeneration in Alzheimer’s disease. But the process can be prevented, raising hopes of a new target for Alzheimer’s treatment. "Scientists have known for a long time that during disease, tau protein gets modified, changes its location in nerve cells and then aggregates,” Benjamin Wolozin, the study's senior author, said in a
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