Neurim Launches Phase 2 Trial to Test Sleep Therapy Piromelatine In Alzheimer’s Patients

Neurim Launches Phase 2 Trial to Test Sleep Therapy Piromelatine In Alzheimer’s Patients
Israel's Neurim Pharmaceuticals is now recruiting up to 500 U.S. patients with mild Alzheimer’s disease for a Phase 2 trial to study the safety and efficacy of its experimental drug, piromelatine. Alzheimer’s is caused by the accumulation of faulty proteins that lead to the formation of beta-amyloid plaques, which greatly interfere with proper neuronal activity and eventually kill neurons. Among other symptoms, Alzheimer's patients may experience poor sleep, which may be related to the accumulation of these plaques. Results of previous preclinical studies suggest that piromelatine — originally studied as a sleep drug — may also improve cognitive function and slow Alzheimer’s progress by promoting better sleep. Piromelatine works in the brain by activating the MT1 and MT2 protein receptors — causing sleep and neuroprotective effects — and the 5-HT1A/D receptors, which are involved in antidepressant and anti-anxiety mechanisms. "This study is the result of recent developments in Alzheimer's disease research that recognizes the role of deep sleep in clearing excessive beta-amyloid from the brain," Amnon Katz, Neurim's vice-president for clinical trials, said in a news release. The company, based in Tel Aviv, cites a "growing body of evidence linking compromised sleep with these p
Subscribe or to access all post and page content.

One comment

Leave a Comment

Your email address will not be published. Required fields are marked *