Anavex Life Sciences Presents New Information on Its Alzheimer’s Therapy Anavex 2-73

Anavex Life Sciences Presents New Information on Its Alzheimer’s Therapy Anavex 2-73
Anavex Life Sciences  has presented new information at a New York conference on Anavex 2-73, which prevented further decline in Alzheimer's patients' mental capacity in a clinical trial last year. Dr. Christopher U. Missling, Anavex’s president and chief executive officer, made the presentation at the Jefferies 2017 Global Healthcare Conference in New York City on June 9. Anavex 2-73 addresses the misfolded proteins involved in several neurodegenerative diseases,  including Alzheimer's. It prompts the sigma-1 and M1 muscarinic receptors to help cells clear misfolded proteins. In preclinical-trial studies before the Phase 2a trial, the company said Anavex 2-73 prevented, stopped, and even reversed Alzheimer's. In November 2016, the company reported that Anavex 2-73 prevented further decline in mental capacity in 32 people with mild to moderate Alzheimer's. The objectives of the Phase 2a study (NCT02244541) were to establish the safety and the maximum dose of Anavex 2-73 that patients could tolerate. During the 41 weeks of treatment, oral doses ranging from 30 mg to 50 mg were well-tolerated, without causing adverse reactions. Two of the trial's secondary objectives were seeing how patients would respond to each dose level and determining whether the therapy could improve cognitive function. Another objective was to determine the drug's b
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      • I think that if it takes them so long to test Anevex 2-73 to a few people in Australia, and retest just those same few people in Australia; so that millions of other people around the world who are getting Alzheimer’s die, or become vegetables, due to the long wait for millions of AD patients to receive Anevex 2-73, that if the drug is successful, that the people’s families, who had family members who died, who did not ever get to receive the drug, because of all of the restrictions of receiving experimental drugs, that those people who are affected by death in their families, those people should go eye for an eye with both the government end of the FDA and the people who work for Anevex as well. An eye for an eye. Equality means suffering and despair are good for everyone. Truly universal suffering. So if your family members turn into vegetables, that could have been prevented by treatment that was withheld due to red tape and procedural handcuffs. Hunt down those who could have saved them later on. Do it randomly as possible. Hate and wait for years if necessary. Be creative, slowly stalk them. The longer you wait, the less they will expect retaliation, and figure out a smart angle so you won’t do anything illegal and get caught for any wrong doing. It may be best to target their family members, and do it legally, to make them suffer, critically suffer, and feel pain, great pain, so that they don’t want to live in such pain, and don’t ever forget the people that they turned down for treatment, and killed, when they didn’t offer their drug to them, due to legal procedures. So, figure out a way, after your family member dies needlessly, to torture these people legally, years later, if necessary, so that they can feel the pain too, of long term family suffering, and losing family members. : ) Feel the Pain Anavex. Taste it. And maybe if enough of them feel the pain, they will change the laws of FDA approvals and trial drug experiments for people who are dying tortuous deaths. If you cause the big wigs enough pain, legally, they will finally think to change the laws. PAIN.
        : ) Have a nice day. Legally. PAIN.

  1. George Andre says:

    My wife is currently at the mild stage. My hope is to stall any further decline. She has been on aricept since diagnosis 18 months ago. We would be very interested to take part in further research. Not sure how to proceed.

  2. Hello!

    Thank you for the article and fascinating information!’I have the same question as MaryBeth Siaggas has asked. My Mother has Alzheimer’s or some form of cognitive decline and is currently on in my opinion too much medication. She is on Aricept,Zoloft and Remeron 60mg a day!!! I am so upset they have her medicated like a zombie. It is the Remeron I am most concerned about, sorry I got off topic.
    How does one get involved in studies like this and when can we expect this medication to be available for the public? This is such a devastating disease, it’s like the Devil has stolen the minds of of our loved ones.
    Thank you and God Bless All those who suffer from any form of cognitive decline along with their families and caregivers <3
    Peace to you All!

  3. Parvin Shariati says:

    Hello there

    Many thanks for this excellent article, which has given many people including myself some hope. My mother is suffering from a kind of dementia that the doctors are still unsure of precisely diagnosing. Her neurologist says that it is not Alzheimer, but yet wants to give her aricept and zoloft medications. She was previously put on memantine which did not work. Given that the doctor says it is not Alzheimer, we are very apprehensive as to giving her these two medications, aricept and zoloft, which I am sure has certain side effects.

    My mother’s dementia is quite severe now. She cant walk anymore, and suffers from incontinence and lack of short-term memory. Her neurologist says that its highly likely to be Normal pressure hydrocephalus (NPH) (or perhaps lewy body dementia), and not Alzheimer. Yet she has recently prescribed my mum to take aricept and zoloft, which we have been told are drugs usually used for Alzheimer. A brain surgeon said that her age (77 years old), together with her diabetes and high blood pressure plus glaucoma may not allow for a successful lumbar puncture and eventual shunt operation to be successful. He did not recommend it.
    Her MRI and CT scans are indicative of age related atrophy, with a hint of small blood vessel disease.
    So we do not know what to do. It is dreadful to see my mother’s conditions deteriorating gradually.
    I wish this new drug could also help us.
    I would be ever so grateful and appreciate it so much if I could be given some guidance and help regarding my mother’s tragic situation.
    I look very much forward to your reply.
    Many many thanks.

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