E-Scape Bio Hits $63 Million in Financing to Develop Alzheimer’s Therapy

E-Scape Bio Hits $63 Million in Financing to Develop Alzheimer’s Therapy
E-Scape Bio, the Gladstone Institutes’ spin-off company working to develop therapies for neurodegenerative disorders such as Alzheimer’s disease, announced that it has raised a total of $63 million in Series A financing from investors. The biotech startup is developing small-molecule drugs that target apoE4, a gene thought to increase the risk of Alzheimer’s disease development. E-Scape Bio aims to develop drugs that correct the adverse effects of the apolipoprotein E4 (apoE4) gene, based on decades of Alzheimer's research done at the Gladstone Institutes by E-Scape Bio’s scientific co-founders Yadong Huang, MD, PhD, and Robert Mahley, MD, PhD, both Gladstone senior investigators. ApoE4 is one form of the gene responsible for producing apolipoprotein E, a naturally occurring protein in the brain that normally helps clear the deposits of amyloid, one of the culprits causing Alzheimer's disease. People with the apoE4 form of apolipoprotein E are at a higher risk of developing Alzheimer’s disease and of earlier development of certain symptoms, such as memory loss. "Alzheimer's is a complex disease involving multiple factors," Stephen Freedman, PhD, vice president of corporate liaison and ventures at Gladstone said in a press release. "Our scientists made significant progress by uncovering the important role of apoE4 in neuron loss and cognitive decline. We wanted to translate their findings into therapeutics t
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