Biogen and Eisai Agree to Work Together on Alzheimer’s Therapy Aducanumab

Biogen and Eisai Agree to Work Together on Alzheimer’s Therapy Aducanumab
Biogen  and Eisai have deepened their partnership by agreeing to work together on the continued development of the Alzheimer’s therapy aducanumab (BIIB037), which targets harmful beta amyloid protein clusters. The U.S. and Japanese companies are already collaborating on the development of elenbecestat (E2609) and BAN2401, which also target beta amyloid. Scientists believe beta amyloid accumulations in the brain cause Alzheimer's by damaging nerve cells.  Aducanumab reduces the build-ups, preclinical-trial studies have shown. Until the Biogen-Eisai agreement, Biogen had been developing aducanumab on its own. It licensed the therapy candidate from Neurimmune, which discovered it. The U.S. Food and Drug Administration gave aducanumab Fast Track status in September 2016 — a designation that will accelerate its review of the treatment. The Japanese Ministry of Health, Labor and Welfare gave aducanumab a similar designation in April 2017. “Through this new agreement, we believe we have improved our ability to maximize the value of aducanumab and expand the potential reach of our industry-leading multiple sclerosis portfolio,” Michel Vounatsos, Biogen's chief executive officer, said in a press release. “The ongoing collaboration between Biogen and Eisai leverages our respective expertise and strengths in our efforts to bring new treatments to patients and families affected by Alzheimer’s disease.” “Genetic epidemiological [disease] studies such as the Icelandic genetic research as well as t
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  1. When are we going to wake up. These drugs are treating a symptom of Alzheimer’s not the cause! Research has reached a tipping point and Aluminum is a causal factor in Alzheimer’s. The good news is dissolved silica effectively removes aluminum from our bodies and brain. Research has shown improved cognition in people with Alzheimer’s after drinking silica for a few months. Check out the research by Dr. Chris Exley at Keele University. For more information on the connection between Aluminum and Alzheimer’s

  2. Bill F. Hefley, Sr. says:

    Given that aducanumab was put on Fast Track status by the FDA in Sep. 2016 what is the current status of aducanumab with the FDA? If it is to become available for general use when can that be expected?

  3. Dante J Marciani says:

    I found perplexing the interest in anti-amyloid monoclonal antibody therapy (a well-deserved interest because of aducanumab results), while dismissing the active immune therapy approach or vaccination as a viable option. An effective vaccination would exert its beneficial actions via natural antibodies produced by the individual, which decrease with age when Alzheimer’s starts to appear. That previously poorly designed vaccines failed, as they were supposed to do, is not a rational justification to ignore a potentially effective preventive approach, assuming that well-designed vaccines are used. This approach becomes more important when the current Alzheimer’s epidemic is taking into consideration.

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