News

Semorinemab Slows Decline in Cognition, Top-line Results Show

Treatment with the investigational anti-tau monoclonal antibody semorinemab significantly slowed decline in a measure of cognition among people with mild-to-moderate Alzheimer’s disease in the Phase 2 LAURIET clinical trial, top-line results show. “The top line results of the Lauriet Phase 2 clinical trial of semorinemab are remarkable in that…

Athira to Begin Open-label Extension Studies of ATH-1017

Athira Pharma, Inc will initiate an open-label extension study for two ongoing clinical trials investigating ATH-1017 to treat Alzheimer’s disease. Both clinical trials — the Phase 2/3 LIFT-AD (NCT04488419) and Phase 2 ACT-AD (NCT04491006) — are investigating ATH-1017, a small molecule designed to enhance the effect of hepatocyte growth…

Space Experiment Could Shed Light on Neurodegenerative Diseases

Researcher Amir Hirsa has found a way 240 miles above the Earth’s surface to study the aggregation of proteins that are the hallmarks of Alzheimer’s and Parkinson’s diseases, and type 2 diabetes. Hirsa, PhD, is a professor of mechanical and aerospace engineering with a joint appointment in chemical and biological engineering…

Documentary Chronicles Father’s Battle With Alzheimer’s

A new documentary released in advance of World Alzheimer’s Day today tells the story of a Worcester, Massachusetts, photographer and art professor who captured the gradual cognitive decline of his late father through a large format black-and-white camera. “With Dad,” which is available to stream on the…

Amyloid-beta Produced in the Liver May Play Role in Alzheimer’s

Amyloid-beta produced in peripheral organs, specifically the liver, may be implicated in the brain neurodegeneration observed in Alzheimer’s disease, according to a mouse study. The study, “Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype,” was published in PLOS Biology. Deposits of amyloid-beta…

Omega-3 Supplements May Slow Memory Decline

Six months of daily supplements of omega-3 increased the levels of two biomarkers of inflammation and nerve damage in the cerebrospinal fluid (CSF) of people with Alzheimer’s disease, according to a post-hoc analysis of data from the OmegAD clinical trial. While these preliminary findings suggest that omega-3 supplements may…