Trametinib, an oral medication approved to treat certain cancers, improved cognition and neuronal health in a mouse model of Alzheimer’s disease, according to a new study. Data suggest the treatment helped to clear toxic protein aggregates from nerve cells. The study, “MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation…
New insights into how nerve cells communicate to control learning and memory are likely to affect how researchers view, and treat, neurodegenerative conditions such as Alzheimer’s disease. British researchers at universities in Bristol and Central Lancashire have discovered they can control a process known as long-term potentiation (LTP) — strengthening the…
After observing similarities in insulin molecular signaling between the pancreas and the brain, Japanese researchers suggest that Alzheimer’s disease is a form of diabetes condition that affects the brain. Their study, “Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy,” recently…
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