New Brain Protein May Play Important Role In Alzheimer’s Disease, Mayo Clinic Study Finds

New Brain Protein May Play Important Role In Alzheimer’s Disease, Mayo Clinic Study Finds
Brain ProteinAn abnormal protein in the brain may play an important role in the onset of Alzheimer's disease, a group of scientists at the Mayo Clinic discovered. Although they still haven't figured out whether this protein, called TAR DNA binding protein of 43kDa (TDP-43), is a cause of Alzheimer's disease or if it develops due to the illness itself, this finding brings new hope to understanding the disease and finding effective treatments. Researchers, who recently discussed the findings at the Alzheimer's Association International Conference in Copenhagen, but who have not yet published the study in a peer-reviewed journal, sought to learn more about the role of the TDP-43, a third protein next to beta-amyloid and tau, which are considered to be the core pathological entities that define Alzheimer's disease. The aim of the study, called “TDP-43 amplifies memory loss and hippocampal atrophy in Alzheimer's disease,” was thus to determine whether this third protein independently has any effect on the clinical and neuroimaging characteristics typically ascribed to Alzheimer's pathology, and whether TDP-43 pathology could help shed light on the phenomenon of resilient cognition in this illness. The Mayo Clinic team screened 342 people who had been diagnosed with intermediate-high probability Alzheimer's disease, looking for the presence, burden, and distribution of TDP-43. They used regression models cont
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