Scientists Evaluate Cancer Drug’s Potential On Alzheimer’s

Scientists Evaluate Cancer Drug’s Potential On Alzheimer’s
oral cancer drug for alzheimer'sA group of scientists is researching the possibility of utilizing a set of compounds developed for cancer treatment as a novel oral therapy for treating Alzheimer’s disease. Up until now, the team had only tested and evaluated injected epothilone D, a brain-penetrant MT-stabilizer, in mice and AD patients. However, in spite of the fact that epothilone D is recognized as a potential treatment for Alzheimer's and cancers, the compound has been limited in use, as the injectable form brings with it a great deal of pain for the patient, Carlo Ballatore, Kurt Brunden and colleagues wanted to test new compounds already identified as potential anti-fungal and anti-cancer therapies “from known classes of non-naturally occurring MT-stabilizing small molecules. This led to the identification of selected triazolopyrimidines and phenylpyrimidines that are orally bioavailable and brain-penetrant without disruption of Pgp function,” they wrote. According to the information provided, the results, published on the ACS’s Journal of Medicinal Chemistry, appear to have confirmed that representative compounds from these series increased MT-stabilization in the brai
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