Brigham and Women’s Hospital Connection Between DNA Methylation & Alzheimer’s Disease

Brigham and Women’s Hospital Connection Between DNA Methylation & Alzheimer’s Disease
alzheimer's DNAResearchers at Brigham and Women's Hospital (BWH) continue to make important contributions to the advancement of further understanding the underlying causes of Alzheimer's disease. After last week's announcement that BWH scientists have determined that decreased brain activity is linked to a decline in the ability to conduct daily tasks associated with Alzheimer's, the institution has followed up with a news release offering new findings from the first large-scale Alzheimer's study that used an epigenome-wide association study (EWAS) approach to looking at the brain's chromosomal make-up and how it relates to those with Alzheimer's disease. Dr. Philip L. De Jager, a researcher for the Program in Translational Neuropsychiatric Genomics, BWH Departments of Neurology and Psychiatry, and the study's lead author said, "Our study approach may help us to better understand the biological impact of environmental risk factors and life experiences on Alzheimer's disease," and adding that, "There are certain advantages to studying the epigenome, or the chemical changes that occur in DNA. The epigenome is malleable and may harbor trac
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