Alzheimer’s Research: Infusion Of Young Blood Can Restore Mental Capabilities In Old Mice

Alzheimer’s Research: Infusion Of Young Blood Can Restore Mental Capabilities In Old Mice
A new study by researchers at the Stanford University School of Medicine has found that some constituent or agent in the blood of young mice when infused to the bloodsteams of old mice has the ability to restore deteriorating mental capabilities. The scientists suggest that if the same phenomenon applies to humans, it could initiate a new paradigm for recharging our aging brains, and potentially result in the development of new therapeutic approaches for treating dementias such as Alzheimer's disease. In the study, published online May 4 in Nature Medicine, entitled "Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice" (published online 4 May 2014; doi:10.1038/nm.3569a) the researchers used sophisticated techniques to investigate numerous important molecular, neuroanatomical, and neurophysiological changes in the brains of old mice that shared the blood of young mice. The study is coauthored by Saul A Villeda, Kristopher E. Plambeck, Jinte Middeldorp, Joseph M. Castellano, Kira I. Mosher, Jian Luo, Lucas K. Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A. Simmons, Xinmin S. Xie, Frank M. Longo and Tony Wyss-Coray, of various Stanford U. and UCSF departments, programs and faculties, The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research at San Francisco, the AfaSci Research Laboratory at Redwood City, California, and the Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System at Palo Alto, California. The researchers observe that as human lifespan increases, a greater proportion of the population is suffering from age-related cognitive impairments, making it important to develop means
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