Houston Methodist’s Nantz National Alzheimer Center Investigational Therapy Focuses On Slowing Alzheimer’s Progression

Houston Methodist’s Nantz National Alzheimer Center Investigational Therapy Focuses On Slowing Alzheimer’s Progression
Almost two-thirds of more than five million Americans currently living with Alzheimer's disease (AD) are women, and American women are twice as likely to die of Alzheimer's disease as they are from breast cancer. According to the Alzheimer's Association, someone in America develops Alzheimer's every 67 seconds, and in 2013, 15.5 million caregivers provided an estimated 17.7 billion hours of unpaid care valued at more than $220 billion. Despite this growing societal problem, exhascerbated by the huge baby boomer cohort now entering senior citizenship, patients with mild to moderate Alzheimer's disease currently have no treatment options to slow brain cell deterioration. Researchers at Houston Methodist Hospital's Nantz National Alzheimer Center are studying an investigational drug that proposes to address that treatment void. The drug, called T-817MA, focuses on preventing brain cell loss and slowing disease progression, whereas current treatment options including Donepezil (Aricept), Rivastigmine (Exelon), and Memantine (Namenda) merely treat the symptoms of mild to moderate Alzheimer's. The researchers want to know whether the investigational therapy using T-817MA can prevent brain cell loss, slowing disease progression in a more fundamental way. Houston Methodist is the only study location in Texas to offer this randomized, double-blind, placebo-controlled study. Approximately two-thirds of study participants will receive active study drug, but neither the patient nor study personnel will know whether a patients has received the active study drug or placebo until the patients' participation in the study is complete. This is a Phase II clinical trial, an early study assessing the efficacy of a drug that has been tested on relatively few research subjects. "
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