Study Reveals Alzheimer’s Patients Have Higher Levels of DNA Modifications in Key Gene

Study Reveals Alzheimer’s Patients Have Higher Levels of DNA Modifications in Key Gene
Alzheimer's DNA ModificationsA research team from the University of Exeter Medical School and King’s College London has uncovered strong evidence of neurological epigenetic changes leading to Alzheimer Disease (AD) development. There are over 26 million people affected by AD worldwide, a chronic neurodegenerative disorder characterized by progressive neuropathology and cognitive decline. Despite the increasing population affected by the disease, not much is known regarding its development in specific brain regions, which has led researchers to investigate and pinpoint novel disease mechanisms to fully understand AD and design improved and effective therapies. Epigenetics refers to functionally relevant changes to the genome that do not change the nucleotide sequence, which means that gene expression can be affected without changing the core DNA sequence. These changes are influenced by the environment and have the capacity to be reverted, becoming potential therapeutic targets. The study, entitled “Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease” and published in the Nature Neuroscience journal, performed cross-tissue analysis of methylomic variation in AD using sampl
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