Study on Neurons’ Function Provide Insight on Alzheimer’s, Other Brain Diseases

Study on Neurons’ Function Provide Insight on Alzheimer’s, Other Brain Diseases
neuronsThe electrically charged cells in the nervous system, called neurons, react differently compared to electrical signals at the molecular level, even though they are the same type of cell, according to new research conducted at the University of Missouri. The variability of the neurons, which are responsible for the interpretation and transmission of information through electrical and chemical signals, may lead to a better understanding of the causes of brain disorders and neural diseases, such as Alzheimer's disease or epilepsy. The research team, led by David Schulz, associate professor in the Division of Biological Sciences in the College of Arts and Science and a researcher in the Interdisciplinary Neuroscience Program at MU, conducted an experiment altering the electrical inputs and outputs in the neurons, using clusters of cells from Jonah crabs. The researchers then measured the messenger RNA (mRNA) levels found. When the normal patterns of stimulation continued, the cells demonstrated correct ratios of mRNA, producing the amount of protein required to keep the electrical impulses. However, the same was not true when they altered the patterns of activity, during which the cells revealed fundamental changes at a molecular level, according to the study conclusions recently published in the 
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