Researchers Unlock Possible Treatment of Network Dysregulation in Alzheimer’s

Researchers Unlock Possible Treatment of Network Dysregulation in Alzheimer’s
shutterstock_156095327In a new study entitled “Metabotropic P2Y1 receptor signaling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model” published in Nature Communications, Andrea Delekate and colleagues examined the astrocytic network underlying pathways that may be implicated in Alzheimer’s disease (AD), and provide solid evidence for the treatment of network dysregulation in AD. Alzheimer disease (AD) is characterized by a progressive decline in cognitive functioning, occurring in people aged 65 years or above. This decline is more prominent in memory, thinking, language and learning capacity. The Alzheimer’s Association estimates that 5.4 million Americans have the disease and that one in eight older people will develop AD. At the moment, AD has no cure and available treatments have shown to only improve memory and cognitive dysfunction temporarily. However, an understanding of the underlying mechanisms that are involved in the pathogenesis of AD may release future pharmacological inputs. The pathogenesis of AD is thought to start by formation and accumulation of toxic amyloid-beta in plaques, leading to cortical network dysfunction. Astrocytes, which support synaptic function and contribute to the regulation of the cerebral blood flow have been found to change their morphology and to be reactive in neurodegenerativ
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