Scientists Study ‘Dementia-in-a-dish’ to Understand Alzheimer’s

Scientists Study ‘Dementia-in-a-dish’ to Understand Alzheimer’s
shutterstock_128636027A new treatment strategy for inherited dementia and Alzheimer's disease was identified using stem cells derived from affected neurons. The study, entitled, “Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia” was recently published in the International Society of Stem Cell Research's journal, Stem Cell Reports. Frontotemporal dementia (FTD) is estimated to comprise half of dementia cases in patients younger than the age of 60. Up to 40% of FTD patients have a familial history, due to genetic mutations in the microtubule-associated protein tau gene (MAPT), progranulin gene (GRN), or C9orf72 gene. The majority of FTD-causing mutations in the GRN are predicted to result in functional null alleles, causing haploinsufficiency. Progranulin (PGRN) has been found to have neurotrophic function in
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