Amyloidosis Links Type 2 Diabetes and Alzheimer’s Disease

Amyloidosis Links Type 2 Diabetes and Alzheimer’s Disease
shutterstock_134873204Researchers at the Uppsala University in Sweden recently found a molecular link between Type 2 Diabetes and Alzheimer’s disease based on a rare condition called amyloidosis that occurs in both conditions. The study is published in the American Journal of Pathology. Amyloidosis results from the accumulation of inappropriately folded proteins called amyloids. When proteins that are normally soluble in water fold to become amyloids, they become insoluble and deposit in tissues or organs, disrupting normal function. In their study titled “In Vivo Seeding and Cross-Seeding of Localized Amyloidosis: A Molecular Link between Type 2 Diabetes and Alzheimer Disease” Gunilla T. Westermark, Ph.D., Department of Medical Cell Biology, Uppsala University, Sweden and colleagues discovered that brain amyloid can motivate the growth of fibrils in the murine pancreas. This pancreatic amyloid can be found in human senile brains. Patients with Type 2 diabetes commonly have Islet amyloid, a polypeptide (IAPP
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