Reduced Glucose Uptake in Brain Exacerbates Alzheimer’s Disease Symptoms

Reduced Glucose Uptake in Brain Exacerbates Alzheimer’s Disease Symptoms
brainAccording to a recent study from researchers at the Keck School of Medicine of the University of Southern California, reduced expression of a protein called GLUT1, responsible for moving glucose in the brain-blood barrier (BBB) worsens Alzheimer's disease cerebrovascular degeneration, neuropathology and cognitive function, suggesting that GLUT1 may represent a therapeutic target for Alzheimer's disease vasculo-neuronal dysfunction and degeneration. The study titled "GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration," was published online this week in peer-reviewed scientific journal Nature Neuroscience. "Our results suggest that GLUT1 deficiencies at the blood-brain barrier are not just symptoms of Alzheimer's but, in fact, lead to a series of vascular injuries that worsen the effects of the disease," said Berislav V. Zlokovic, M.D., Ph.D., director of the Zilkha Neurogenetic Institute (ZNI) at the Keck School of Medicine, the Mary Hayley and Selim Zilkha Chair for Alzheimer's Disease Research and the study's principal investigator. "We do
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *