Connection Between Alzheimer’s Disease and Diabetes Uncovered in Recent Research

Connection Between Alzheimer’s Disease and Diabetes Uncovered in Recent Research
In a recent study published in The Journal of Clinical Investigation, a team of researchers at the Washington University School of Medicine in St. Louis found an association between Alzheimer's disease and diabetes, which provides evidence on the fact the Alzheimer’s may be affected by elevated blood sugar. This new study conducted in mice revealed that increased levels in glucose in the blood increased the levels of amyloid beta, a key feature of brain plaques in patients with Alzheimer's disease. "Our results suggest that diabetes, or other conditions that make it hard to control blood sugar levels, can have harmful effects on brain function and exacerbate neurological conditions such as Alzheimer's disease," said lead author Shannon Macauley, PhD, a postdoctoral research scholar in a recent news release "The link we've discovered could lead us to future treatment targets that reduce these effects." Diabetes causes uncontrolled glucose levels in the blood, so many patients rely on insulin and other drugs to maintain their blood sugar levels controlled. In their investigation, the researchers infused glucose in mice models of Alzheimer's disease, with results showing that in young mice without amyloid plaques in their brains, doubling glucose levels in the blood resulted in an increase of 20% of amyloid beta levels in the brain. Then, in older mice that already had developed brain plaques, they repeate
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