Aphios Granted Patent For Treatment Of Alzheimer’s Disease

Aphios Granted Patent For Treatment Of Alzheimer’s Disease
Aphios Corporation recently announced that United States Patent 9,034,347 has been granted to the company's lead compound to treat neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Hutchinson Disease and Down's syndrome. Alzheimer's disease, Parkinson's disease, Hutchinson's Disease, Kuru Creutzfeldt-Jakob disease, further spongiform encephalopathies and all neurodegenerative diseases in general remain enormous health problems with numerous unmet medical needs. There are limited resources to address these diseases from a therapeutic standpoint. Alzheimer's, Parkinson's and Hutchinson's diseases tend to occur in older people and symptoms manifest as the diseases progress. These diseases make individuals less able to take care of themselves. Trevor P. Castor who is the Aphios Corporation's CEO, said: “It is therefore highly desirable to have simple therapies which can be administered (e.g. oral formulations) without the need for specially trained healthcare providers.” Castor continued: “Our recent in vitro studies have shown that our lead Alzheimer's disease drug candidate, APH-1104, a potent analog of Bryostatin-1, is neuroprotective by α-secretase activation via novel PKC isoforms, down-regulation of pro-inflammatory and angiogenic processes and the substitution of β-amyloid for its soluble and harmless relative, sAPP-α at concentrations which are orders of magnitude lower than conventional
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