Potential Therapeutic Strategy for Alzheimer’s Disease Based on Insulin

Potential Therapeutic Strategy for Alzheimer’s Disease Based on Insulin
A study recently published in the Journal of Alzheimer's Disease revealed that intranasal administration of insulin can be a potential therapeutic strategy for Alzheimer’s disease and dementia conditions. The study entitled “Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition” was conducted by researchers at the University of Washington Medicine, Veteran's Administration Puget Sound and Saint Louis University. Alzheimer’s disease is a neurodegenerative disorder characterized by cognitive and behavioral problems. It is the most common form of dementia in the elderly with patients initially experiencing a memory loss and confusion that gradually leads to behavior and personality changes, a decline in cognitive abilities and ultimately to severe loss of mental function. Alzheimer’s disease is characterized by the loss of neurons responsible for memory and learning, and brain formation of amyloid plaques (containing sticky beta-amyloid proteins). It is estimated that 44 million people worldwide suffer from Alzheimer's or other form of dementia. Several studies have suggested that diabetes and insulin abnormalities can contribute to Alzheimer’s disease pathophysiology and clinical symptoms. In fact, intranasal insulin has shown efficacy in Alzheimer’s disease patients, although it is unclear whether and how insulin reaches the brain. In the study, rese
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *