Alzheimer’s Disease Patients Have Fat Deposits in the Brain, According To Study

Alzheimer’s Disease Patients Have Fat Deposits in the Brain, According To Study
In a recent study entitled “Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease”, published in the journal Cell Stem Cell, a team of Canadian researchers led by Dr. Karl J. L. Fernandes found that fat droplets accumulate in the brains of Alzheimer’s disease (AD) patients. Notably, these droplets localize in brain niches responsible for maintaining tissue structure and function. AD was first described by the German psychiatrist and pathologist Alois Alzheimer in 1906. The disease is characterized by loss of neurons in the cerebral cortex along with hippocampal atrophy, causing progressive cognitive impairment. Nowadays, over 47.5 million people worldwide have Alzheimer's disease or some other type of dementia. Available treatments can reduce symptoms, however, they are unable to effectively prevent the disease. Researchers have provided another step towards AD treatment by relating lipid accumulation in the brain, a previous observation by Alois Alzheimer, with disease progression.  "We found fatty acid deposits in the brain of patients who died from the disease and in mice that were genetically modified to develop Alzheimer's disease. Our experiments suggest that these abnormal fat deposits could be a trigger for the disease", said Dr. Fernandes in a recent news r
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