Study Sheds Light Into Alzheimer’s Disease Pathogenesis

Study Sheds Light Into Alzheimer’s Disease Pathogenesis
Alzheimer’s Disease (AD) has been a topic of extensive research over the past three decades. The main focus of many studies has been the neurotoxicity associated with the accumulation of insoluble proteinaceous complexes in the brain. Closer examination has revealed these complexes to be plaques formed due to aggregation of small fragments of beta-amyloid peptides, which are proteolytic derivatives of a precursor protein APP (as a result of sequential action of two enzymes). It has been known that beta-amyloid hyperactivated neurons led to neurotoxicity. However, a recent study published in Nature has shown that this was only one side of the story as far as pathogenesis of AD was concerned,
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *