Scientists Develop An Early Warning Gene Signature For Alzheimer’s

Scientists Develop An Early Warning Gene Signature For Alzheimer’s
A gene signature that could be used to predict the onset of diseases, such as Alzheimer's, years in advance has been developed in a study published in the open access journal Genome Biology. The objective of the study, entitled "A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status" (Genome Biology 2015, 16:185 doi:10.1186/s13059-015-0750-x), was to define a set of genes associated with healthy ageing in 65 year olds -- molecular profiling that could be useful for distinguishing people at earlier risk of age-related diseases and a substantial improvement over reliance on chronological age and complementary traditional indicators of disease, such as blood pressure. The researchers note that improved diagnostics of the human aging process may help predict future healthcare needs or guide preventative measures for tackling diseases associated with older age. The scientists explain that they used transcriptomics; study of the transcriptome -- the complete set of RNA transcripts (eg: mRNA, rRNA, tRNA and others) -- that are produced by the genome under specific circumstances or in a specific cell using high-throughput methods, such as microarray analysis. They used this method to build the first reproducible multi-tissue RNA expression signature by gene-chip profiling tissue from sedentary normal subjects who had reached 65 years of age in good health, and used the information to develop a signature of 150 RNA genes that indicated healthy ageing. With this RNA signature, which was found to be a reliable predictor f
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