Reasearchers Find Hormone Injections Can Spread ‘Seeds’ of Alzheimer’s Disease

Reasearchers Find Hormone Injections Can Spread ‘Seeds’ of Alzheimer’s Disease
A recent study published this week in Nature has revealed that the “seeds” of Alzheimer’s disease and related brain disorders may be transmitted by direct tissue transplantation. The results from the study entitled “Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy”, coupled with findings from other recent investigations, could provide a new understanding on how prions, rogue proteins similar to those that lead to Mad Cow disease, develop and potentially spread in the brain. Study authors analyzed the brains of eight people that showed signals of Creutzfeldt-Jakob disease development caused by treatments with contaminated growth hormones from human cadavers decades before. Six of the eight patients also had an increase in amyloid plaques, a well-established cause of Alzheimer’s Disease. “This is the first evidence of real-world transmission of amyloid pathology,” John Hardy, a University College London molecular neuroscientist, reportedly told the journal according to a recent news release “It is potentially concerning.” The hormone treatments were given to people short in height and the samples for the study were collected from cadavers’ pituitary glands, however, they were contaminated with prions. The treatments began in 1958, and due to reports of Creutzfeldt-Jakob they were halted in 1985. In 2000 the results showed that 38 of the patients had developed the disorder and in 2012 there were 450 cases among the recipients of the cadaver-derived HGH and other clinical procedures such as brain surgery and transplants. "This is potentially very important research,” added Mike Hanna, Director of the UCL Institute of Neurology. “It could inform our understanding of the molecular mechanisms le
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