Study Finds Novel Gene Associated With Alzheimer’s Disease Development

Study Finds Novel Gene Associated With Alzheimer’s Disease Development
In a study recently published in the journal Brain a team of researchers found an immune system gene associated with higher rates of amyloid plaque buildup in the brains of patients with Alzheimer’s Disease and older adults at risk for the condition. The mechanisms underlying amyloid accumulation, the known cause of Alzheimer’s disease (AD), are not fully understood. Pathogenic mutations causing rare, early-onset forms of AD have been described in three genes involved in amyloidogenesis, APP (amyloid precursor protein), PSEN1 and PSEN2. For late-onset AD, the strongest known genetic risk factor is the APOE e4 allele. Several mechanisms have been proposed linking APOE e4 to enhanced aggregation and reduced clearance of brain amyloid. However, APOE e4 is neither necessary nor sufficient for the development of amyloid pathology or incident AD, suggesting that other contributing factors remain to be discovered. In the study entitled “GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP, the multi-institutional research team led by scientists at the Indiana University School of Medicine performed a genome-wide assoc
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *