Alzheimer’s Proteins In Brain Tissue Extracted More Easily by New Technique

Alzheimer’s Proteins In Brain Tissue Extracted More Easily by New Technique
Researchers from NYU Langone Medical Center developed a novel strategy to extract large quantities of brain protein from formalin-fixed, paraffin-embedded (FFPE) tissues in patients with Alzheimer's, an advancement that may lead to a new understanding of brain protein changes found in the disease. The study entitled "Proteomic analysis of neurons microdissected from formalin-fixed, paraffin-embedded Alzheimer’s disease brain tissue" was published in Scientific Reports. Neurodegenerative brain disorders like Alzheimer’s, which affect an estimated  5.3 million people — mostly older women — in the U.S.,  share some common symptoms, like recent-event memory loss, poor judgment, confusion, and changes in mood and personality. Though advances in science have led to progress in understanding some aspects related to Alzheimer’s, the disease's exact causes and underlying mechanisms are not fully known. Evidence to date points to several risk factors that contribute toward Alzheimer’s development, including genetics, infections with herpes simplex virus, and decreased synthesis of the neurotransmitter acetylcholine. Other studies highlight the presence of abnormal levels of extracellular amyloid beta (Aβ) plaque deposits and tau protein in brain tissue. These folded proteins are generally insoluble, which makes them difficult to study using FFPE tissue, or tissue saturated in wax and cut for analysis that is widely available for medical
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