Alzheimer’s Risk Linked to Prostate Cancer Therapy in Study

Alzheimer’s Risk Linked to Prostate Cancer Therapy in Study
Men undergoing androgen deprivation therapy (ADT) for prostate cancer  could be almost twice as likely to be diagnosed with Alzheimer's disease (AD) than those not treated with ADT. The findings, in a study published in the Journal of Clinical Oncology, also show that the risks of developing Alzheimer's might continue to rise as the duration of ADT treatment lengthens. Analysis, conducted by Penn Medicine and Stanford University researchers, was based on the medical records from two large hospital systems. The results do not prove definitely that ADT increases the risk of Alzheimer's development, the researchers noted. But, they said, they clearly point in that direction, and are in line with evidence that low testosterone levels may weaken an aging brain's resistance to AD. "We wanted to contribute to the discussion regarding the relative risks and benefits of ADT, and no one had yet looked at the association between ADT and Alzheimer's disease," lead author Kevin T. Nead, MD, MPhil, a resident in the department of Radiation Oncology at the Perelman School of Medicine at the University of Pennsylvania, and a fellow at Penn's Leonard Davis Institute of Health Economics, said in a recent news release. "Based on the results of our study, an increased risk of Alzheimer's disease is a potential adverse effect of ADT, but further research is needed before c
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