Alzheimer’s Drug Moves into Phase 1 Safety Study

Alzheimer’s Drug Moves into Phase 1 Safety Study
Tetra Discovery Partners, in collaboration with the NIH Blueprint Neurotherapeutics Network, announced the start of Phase 1 safety trials of BPN14770, a drug Tetra is developing as a potential treatment for neurological disorders such as Alzheimer’s disease (AD) and one that aims to both improve memory and slow disease progression. The NIH Blueprint Neurotherapeutics Network is a program designed to discover and develop novel treatments for neurological diseases by providing support for small molecule drug discovery and development from hit-to-lead chemistry through Phase I testing. BPN14770 is the first compound under the program to reach a clinical trial. “We are pleased that BPN14770 has moved into a clinical study and we are eagerly awaiting the outcomes of the safety trial,” Amir Tamiz, PhD, program director at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS), said in a press release. BPN14770 is a phosphodiesterase 4D negative allosteric modulator (PDE4D-NAM), designed to both improve memory and slow AD progression. Research has shown that the brain neuronal enzyme phosphodiesterase sub-type 4D (PDE4D) modulates the formation of new synaptic connections between neurons, and plays a key role in learning and memory storage. Rolipram is a different type of
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