CurePSP Nonprofit Focuses on Neurodegenerative Conditions, Including Alzheimer’s Disease

CurePSP is a Maryland-based nonprofit organization that focuses on neurodegenerative diseases that strike when people are in their 50s to 70s, including Alzheimer's disease. PSP stands for progressive supranuclear palsy, which is a neurodegenerative disorder that impacts movement, walking, speech, balance, mood, vision, behavior, and cognition. Like Alzheimer's, PSP is characterized by deposits of the tau protein in the brain, which may contribute to neuronal cell death. Although the emphasis of the organization started with PSP, efforts expanded to other diseases characterized by tau, such as Alzheimer's. One example includes CurePSP support of an Alzheimer's disease medication known as TPI-287, which targets brain tau and is currently in a Phase 1 clinical trial in humans. Researchers at the University of California, San Francisco, are currently recruiting patients for the study, which includes people ages 50 to 82 with probable Alzheimer's disease. Adam Boxer, M.D., Ph.D., heads up the research efforts. According to UCSF's website, "The purpose of this study is to determine the dose of TPI-287 that is safe and tolerable in people with mild to moderate Alzheimer's, as well as to measure the properties and preliminary efficacy of TPI-287." As a Phase 1 study, it is the first step for understanding how the drug may work in humans. The one-year study involves brain magnetic resonance imaging (MRI), spinal fluid assessment, as well as neurological, physical and cognit
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