Synaptic Loss Precedes Alzheimer’s Symptoms and Drives Disease, New Study Finds

Synaptic Loss Precedes Alzheimer’s Symptoms and Drives Disease, New Study Finds
Before any signs of cognitive decline start showing, neuronal synaptic connections are lost in mice destined to develop Alzheimer’s. New research shows that microglia – brain immune cells – destroy synapses in a fashion resembling processes in the developing brain, suggesting that it might be possible to develop drugs targeting disease at far earlier stages. The process of synaptic pruning – the loss of neuronal connections – is crucial for producing distinct neuronal circuits during normal brain development. When synapses are not successfully eliminated, conditions such as autism might arise. Excessive pruning has also been suggested to contribute to psychiatric conditions such as schizophrenia. It is easy to envision how disruption of these developmental processes might lead
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *