New Research Reveals Certain Protein Protects Against Neurodegenerative Diseases

New Research Reveals Certain Protein Protects Against Neurodegenerative Diseases
A new study led by biomedical scientists at Indiana University has revealed evidence that the NMNAT2 enzyme may be protective against the debilitating effects of certain degenerative disorders, including Alzheimer's Disease. The study, “NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies,” was published in the journal PLOS Biology. According to a news release,  the study found that NMNAT2, or nicotinamide mononucleotide adenylyl transferase 2, is a key neuronal maintenance factor. "It exerts both an enzyme function to protect neurons from stress caused by over-excitation, and a 'chaperone' function, shown for the first time in this study, to combat the misfolded proteins encountered by the brain during aging." said Hui-Chen Lu, a professor in the Linda and Jack Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, at IU Bloomington College of Arts and Sciences. Many neurodegenerative diseases result from the build-up of certain proteins in the brain. These disorders, called proteinopathies, occur when proteins "misfold," causing them build-up in the brain in the form of plaques or "tangles." NMNAT2 binds to misfolded proteins and repair or prevent the faults that cause the build-up. The most common
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