Blood Progranulin May Not Be Suitable Alzheimer’s Marker After All, Researchers Find

Blood Progranulin May Not Be Suitable Alzheimer’s Marker After All, Researchers Find
Recent hopeful statements that blood levels of progranulin might be a biomarker for Alzheimer’s disease and other forms of dementia came to an abrupt stop when a recent study demonstrated that there is no link between the blood and cerebrospinal fluid levels of the substance, disrupting the idea of a progranulin blood test for dementia. The study, however, advances our understanding of disease processes in dementia, and prevents future studies from following the wrong track. While mutations in the progranulin gene, GRN, have been linked to hereditary forms of dementia, researchers agree that the factor also plays an important part in sporadic dementia cases where no mutations are present. Based on these findings, scientists had proposed that low levels of progranulin could serve as a
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