Alzheimer’s Inhibitor BACE to Enter Worldwide Phase 2/3 Trial

Alzheimer’s Inhibitor BACE to Enter Worldwide Phase 2/3 Trial
Alzheimer's Therapeutic Research Institute (ATRI) at the University of Southern California, and Janssen Research & Development will collaborate for a  Phase 2/3 clinical trial of Jansen’s BACE blocker intended to delay or even prevent Alzheimer’s symptoms. The BACE blocker is a drug that prevents the action of an enzyme involved in the production main cause of plaque build-ups in the brains of Alzheimer’s patients - amyloid-β protein. People who currently show no Alzheimer’s symptoms but are older than age 60 and have an accumulation of amyloid-β in their brains, will be the focus of the study. Participants will be followed over time, while repeatedly being tested for amyloid-β levels and cognitive performance. The participants will be randomized to receive either the drug candidate or placebo in a double-blind manner. "We are now looking at the stage of Alzheimer's that precedes even mild symptoms," said Paul Aisen, founding director of USC ATRI and professor of neurology at the Keck School of Medicine, in a news release. "It is our view that drugs such as BACE inhibitors may be most effective at the earliest stages of the disease." Enrolling 1,600 patients worldwide, the trial will encompass treatment centers in North America, Europe, Japan, and Australia. In North America alone, 660 participants across 75 centers will be included. Aisen and Reisa Sperling, director of the Center for Alzheimer's Resear
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