Alzheimer’s Inhibitor BACE to Enter Worldwide Phase 2/3 Trial

Alzheimer’s Inhibitor BACE to Enter Worldwide Phase 2/3 Trial
0
(0)

Alzheimer’s Therapeutic Research Institute (ATRI) at the University of Southern California, and Janssen Research & Development will collaborate for a  Phase 2/3 clinical trial of Jansen’s BACE blocker intended to delay or even prevent Alzheimer’s symptoms.

The BACE blocker is a drug that prevents the action of an enzyme involved in the production main cause of plaque build-ups in the brains of Alzheimer’s patients – amyloid-β protein.

People who currently show no Alzheimer’s symptoms but are older than age 60 and have an accumulation of amyloid-β in their brains, will be the focus of the study.

Participants will be followed over time, while repeatedly being tested for amyloid-β levels and cognitive performance. The participants will be randomized to receive either the drug candidate or placebo in a double-blind manner.

“We are now looking at the stage of Alzheimer’s that precedes even mild symptoms,” said Paul Aisen, founding director of USC ATRI and professor of neurology at the Keck School of Medicine, in a news release. “It is our view that drugs such as BACE inhibitors may be most effective at the earliest stages of the disease.”

Enrolling 1,600 patients worldwide, the trial will encompass treatment centers in North America, Europe, Japan, and Australia. In North America alone, 660 participants across 75 centers will be included.

Aisen and Reisa Sperling, director of the Center for Alzheimer’s Research and Treatment at Harvard Medical School, will be co-principals of the investigation.

ATRI is being financially supported for the project via funding by Jansen. Both groups will oversee the study with ATRI managing study centers in the U.S. and Canada. Sites in the remaining nations will be managed by Quintiles.

“There is a lot of optimism that research may be ushering in a new era in Alzheimer’s drug development,” said Gary Romano, head of Alzheimer’s disease clinical development at Janssen. “We may be able to treat the disease using interventions before it becomes advanced, much like you treat high cholesterol to mitigate the risk of heart attacks.”

Jansen’s BACE blocker is licensed from the Japanese pharmaceutical company Shionogi & Co.

Magdalena is a writer with a passion for bridging the gap between the people performing research, and those who want or need to understand it. She writes about medical science and drug discovery. She holds an MS in Pharmaceutical Bioscience and a PhD — spanning the fields of psychiatry, immunology, and neuropharmacology — from Karolinska Institutet in Sweden.
×
Magdalena is a writer with a passion for bridging the gap between the people performing research, and those who want or need to understand it. She writes about medical science and drug discovery. She holds an MS in Pharmaceutical Bioscience and a PhD — spanning the fields of psychiatry, immunology, and neuropharmacology — from Karolinska Institutet in Sweden.

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?