Alzheimer’s Disease: Zinc Transporters May Shed Light on Molecular Mechanism

Alzheimer’s Disease: Zinc Transporters May Shed Light on Molecular Mechanism
Unbalanced, unhealthy zinc levels show in many diseases including Alzheimer's disease, Parkinson's disease, and pancreatic cancer. But lack of information about the molecular structure of zinc transporters hampers the discovery of new drugs to bring zinc to proper levels (homeostasis) with other important elements. Researchers at Michigan State University (MSU) have taken a new step toward the development of such drugs, by providing a crystal structure of the extracellular domain (ECD) of ZIP4, a protein expressed by cells that line the intestine and are involved in the uptake of zinc from food. The study, "Structural insights of ZIP4 extracellular d
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