Alzheimer’s Disease First Steps Revealed by Mouse Brain in a Dish

Alzheimer’s Disease First Steps Revealed by Mouse Brain in a Dish
Using slices of mouse brain tissue kept alive in a lab dish, scientists have identified the earliest molecular changes leading to Alzheimer’s disease. The findings, showing how early alterations in brain amyloid-β balance causes nerve connections called synapses to die, might allow scientist to target the mechanisms and develop therapies to prevent or postpone disease. Once a patient receives an Alzheimer’s diagnosis, extensive brain changes involving deposits of amyloid-β protein, referred to as plaque, are already present. Identifying the first steps leading to Alzheimer’s is a crucial step towards the development of a drug capable of this task. Until now, science has been hampered by poor models of the disease, studying brains of deceased patients or mice bred to mimi
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