Dementia in Alzheimer’s May Result from Dual Blow to Brain: Amyloid Clumps and Tau Tangles

Dementia in Alzheimer’s May Result from Dual Blow to Brain: Amyloid Clumps and Tau Tangles
Amyloid-β plaques accumulating in the brain alone are not enough to cause the dementia that characterizes Alzheimer’s, new research from Johns Hopkins University argues. Instead, a second blow — molecular pathways that ultimately cause tau proteins to form tangles inside nerve cells — is also needed for neurons to degenerate. The study, “The neuritic plaque facilitates pathological conversion of tau in an

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