Researchers Uncover Gene Control Mechanism That Holds Promise as Alzheimer’s Treatment

Researchers Uncover Gene Control Mechanism That Holds Promise as Alzheimer’s Treatment
Researchers report identifying the molecular mechanisms responsible for activating the neuroglobin gene, which scientists think may protect people from developing Alzheimer’s disease. Moreover, the researchers suggest that scientists should explore ways of activating the gene as potential treatments for Alzheimer’s disease. The study, titled “Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach” and published in the journal Nucleic Acids Research, was a joint effort between researchers from Hong Kong University, the MRC Clinical Sciences Centre at Imperial College London, U.K., and Erasmus University in the Netherlands. Earlier studies have shown that mutations in neuroglobin are linked to an inherited form of Alzheimer’s. Studies also show the protein produced by the gene tends to decrease as people age and is lower in women than in men. Age and female sex are among the best-known risk factors for Alzheimer’s. Scientists also have suggested that the factor is neuroprotective, preventing damage to nerve cells caused by low oxygen levels, oxidative stress and mechanical injuries. Scientists have not known how neuroglobin is activated, so, the research team decided to explore the molecular mechanisms of neuroglobin activation. The process of switching genes on and off is controlled by numerous factors. Molecules called transcription fac
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *