vTv Therapeutics to Detail Potential Alzheimer’s Treatment, Now in Phase 3 Study, at Meeting Today

vTv Therapeutics to Detail Potential Alzheimer’s Treatment, Now in Phase 3 Study, at Meeting Today
Larry Altstiel, MD, PhD, chief medical officer of vTv Therapeutics, will speak today on the panel “Novel Approaches to Alzheimer’s Disease,” during the Neuro Advance Boston conference hosted by Harvard Medical School. Altstiel will detail the mechanisms of action of azeliragon, vTv Therapeutics' investigative treatment for mild Alzheimer’s disease (AD), in his Oct. 5 presentation, according to a press release. The treatment is currently in a Phase 3 clinical trial in people with mild Alzheimer's, which is recruiting patients. Azeliragon blocks the receptor RAGE (Receptor for Advanced Glycation Endproducts) in the brain. Normally found in low numbers in a healthy brain, RAGE numbers increase during inflammation. Examinations of deceased Alzheimer’s patients and biologic investigations indicate that RAGE numbers seem to correlate with AD severity and progression. RAGE in higher number affects both neurons and glial cells in the brain, and is also linked to blood vessel dysfunction — another key factor that influences dementia development. Preclinial studies have shown that blocking the receptor RAGE impacts several processes that researchers believe contribute to Alzheimer’s. It reduces the accumulation of amyloid-beta and prevents the formation of fibrils made up of the tau protein. Azeliragon also dampens brain inflammation. At the Alzheimer’s
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