Researchers Explore New Way to Deliver Memory Loss Treatment to the Brain

Researchers Explore New Way to Deliver Memory Loss Treatment to the Brain
A treatment that uses microscopic droplets of fat – called nanoliposomes - to carry drugs to the brain has  been used effectively to target cancer cells. Now the technique has shown promise in restoring memory loss in mice models of Alzheimer's disease, according to a new study funded by the Alzheimer’s Society. The study, “Retro-Inverso Peptide Inhibitor Nanoparticles As Potent Inhibitors Of Aggregation Of The Alzheimer's Aβ Peptide,” was published in the journal Nanomedicine: Nanotechnology, Biology and Medicine. The hallmark of Alzheimer’s disease is the toxic accumulation of the beta-amyloid protein, which blocks the proper functioning of neurons. This new treatment delivers nanoliposomes decorated with protein particles that can stop the accumulation of the beta-amyloid protein. The fat molecules that the nanoliposomes are made of fuse with the cell’s envelope, delivering the protein fragments into neurons. Researchers observed that, even in low amounts, the protein particles rescued cultured neurons from the toxic effect of accumulated beta-amyloid. They also observed that injecting the nanoliposomes containing the protein fragments in mice with Alzheimer’s disease for three weeks provided protection against memory loss. “As the most potent [beta-amyloid] aggregation inhibitor that we have tested so far, we propose to develop [protein particles] as a potential disease-modifying treatment for [Alzheimer’s disease],” the study authors wrote. Recent studies have shown that nanoliposomes can pass directly into the brain through the nose, sugges
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *