AdAlta and Crossbeta Enter Alzheimer’s Disease-Specific Shark Antibodies Agreement

AdAlta and Crossbeta Enter Alzheimer’s Disease-Specific Shark Antibodies Agreement
AdAlta and Crossbeta Biosciences have entered into a commercialization agreement, granting Crossbeta with a license to three beta-amyloid oligomer (AßO)-specific shark antibodies, considered to have disease-specific potential for the diagnosis and treatment of Alzheimer’s disease (AD). These three shark antibodies were identified under a December 2013 agreement between the two companies. The research and development collaboration used AßOs produced by Crossbeta’s technology of stable oligomers, and AdAlta’s shark antibody portfolio, to screen these novel targets in order to identify the best therapeutic and diagnostic candidates. Proteins are long linear chains of a variety of building blocks (amino acids). To function properly, these chains must be folded in a specific manner. However, sometimes, misfolded proteins stick together, forming aggregates that can be very toxic. In AD, oligomers (molecular complex) of amyloid-beta protein cause death of brain cells that have an important function in memory. Having a drug that detoxifies these oligomers may prevent further damage in early stage AD. Unfortunately the instability and limited characterization of oligomer preparations have seriously impeded research and development in this field. Crossbeta’s portfolio is based on stable oligomers of several peptides including amyloid beta (1-42 and pGlu3-42) and alpha-synuclein. AdAlta’s technology platform mimics the shape and engineers key stability features of the antigen-binding domain of shark antibodies into human proteins to create unique compounds, called i-bodies, for therapeutic intervention in diseases. The three
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