Alzheimer’s May Share Similar Disease Mechanisms with Diabetes, Researchers Say

Alzheimer’s May Share Similar Disease Mechanisms with Diabetes, Researchers Say
After observing similarities in insulin molecular signaling between the pancreas and the brain, Japanese researchers suggest that Alzheimer’s disease is a form of diabetes condition that affects the brain. Their study, “Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy,” recently appeared in the journal Molecular Psychiatry. The research team at the Graduate School of Pharmaceutical Sciences at Tohoku University in Japan noted that a drug used to treat Alzheimer’s disease called Namenda (memantine) blocks a potassium channel in the brain. This channel, called Kir6.2, is involved in insulin signaling in the pancreas, and is important for diabetes processes. When the channel gets blocked in the pancreas, it increases insulin, which in turn reduces the levels of blood sugar. The team performed experiments in mice, showing that blocking the channel with memantine improved long-term potentiaion in the hippocampus — a brain region crucial for memory formation. Long-term potentiation is a measure of the strength of connections between neurons, which is believed to underlie the memory-forming capacity of the brain. When the team used another compound, which prevented the drug from blocking the potassium channels, the effects were lost. The suspicion that the channel was involved in the memory-forming capacity of the mice was also confirmed by breeding mice that lacked the channel from birth. These animals showed severe memory problems and reduced long-term potentiation of nerve connection in the hippocampus. "
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