Extremely High Aluminum Levels Found in Brains of Familial Alzheimer’s Patients

Extremely High Aluminum Levels Found in Brains of Familial Alzheimer’s Patients

A group of patients with inherited forms of Alzheimer’s disease was found to have extremely high brain-aluminum levels, leading researchers to suggest there might be a link between genetic vulnerability to the condition and a higher susceptibility to accumulate aluminum in the brain.

“Aluminium in brain tissue in familial Alzheimer’s disease” recorded some of the highest brain-aluminum levels ever measured, and suggested that the metal could be a factor in amyloid-beta aggregation. The report was published in the Journal of Trace Elements in Medicine and Biology.

Abnormally high aluminum levels have been found in the brains of patients with sporadic Alzheimer’s, but no studies had examined levels in patients with familial versions of the neurodegenerative condition.

Researchers at Keele University in England autopsied the brains of 12 familial Alzheimer’s patients. The patients were 42 to 86 years old and had been diagnosed by genetic analysis or the presence of disease in close relatives, along with an early disease onset.

The team found aluminum in all 144 brain parts examined. Levels above 2 micrograms per gram of tissue are considered concerning, and about 40% of all the examined tissue had content higher than that. More than half the tissue — 58% — had levels higher than 3 micrograms, which is considered a significant hazard.

In 11 of the patients, the team found at least one brain region with aluminum levels in a hazardous range. Five patients had levels higher than 10 micrograms, with the highest concentration being 35.65 micrograms per gram of tissue.

Aluminum amounts that high typically are only found in cases of aluminum-triggered encephalopathy, a brain disease that can develop as a result of a person’s occupation or significant exposure to aluminum-containing drugs.

Researchers also found aluminum deposits in the gray matter, concentrated in clusters.

They noted that the extracellular deposits looked like amyloid-beta deposits.

“These data, supported by visual evidence of aluminium in brain tissue, raise the possibility that genetic predisposition to AD is accompanied by a higher propensity to accumulate and retain aluminium in the brain,” the researchers wrote.

In earlier work, the team showed that aluminum clustered in the same spots as amyloid-beta in the brain of an Alzheimer’s patient. Other studies have shown that amyloid-beta binds aluminum, which triggers precipitation of amyloid aggregates.

Amyloid-beta’s role in familial Alzheimer’s is more established than its part in sporadic cases. These data indicate that aluminum can contribute to all types of Alzheimer’s disease.


  1. Laura says:

    Thank you for this article. Many still argue that there is no link between aluminum and health consequences, despite scientists and researchers showing it’s potential and probable impact.
    There’s a documentary about aluminum called Age of Aluminum, based on book Dirty Little Secret – The Aluminum Files. I strongly reccomend looking into this topic further.
    I would say please do your own research and avoid putting trust in those who try to “debunk” valid claims.

  2. Wadala A. Bashir says:

    Aluminium ion is a highly attractive oxygen-containing species.
    This property might hinder many biochemical processes that will lead to the disease. If so,this will lead me to the synthesis of
    a novel reagent for the treatment and recovery.

  3. Wadala A. Bashir says:

    The high concentration of ethanol in wine, and when the later is stored in glass bottles, will lead to the leaching of aluminium by ethanol due to some sort of complex formation. The injection of this complex will lead to the accumulation of aluminium in the body.

  4. Jim Duncalf says:

    When I was very young back in the late 1940s I remember my father refusing to eat anything cooked in an Aluminum pot nor did he allow the use of aluminum foil in our cooking. He pointed out that Aluminum and Zink both have two electrons in their outer shell (also mercury and lead) but have different masses and conductivity. Zink is used by our body in many processes and if aluminum takes its place it could cause a breakdown in the ability tor our cells to divide and for the electrical impulses used in our nervous system to properly conduct nerve impulses. He convinced me and virtually all the family that Aluminum could cause long term harm to the human body. I am not sure how he came to this theses.. But it’s good to see this theory recognized and now proven.

    • Ellen Johnson says:

      My grandmother only used cast iron for cooking. When my mother changed to aluminum my father threw a fit because she would not change back to cast iron. Throughout the years I used stainless steel only to discover that Diane’s stainless 6 long steel trachea contains nickel in it. Now I am considering cast iron for cooking. Have you any comments or thoughts? Thank you.
      Ellen Johnson

  5. Jen says:

    I believe this a hundred percent as my dad was abusing drogs for over 20 years consuming them from aluminium foil. Now he suffers from Alzheimer’s. I’m sure that this is strongly linked!

  6. Kat says:

    So with in the increase in vaccinations constantly being pushed at us and young children it would be interesting to note the vaccination schedules of the patients tested as aluminum is an adjuvant used in many vaccines. Why is this question often overlooked and left out of studies one must wonder?

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