AXON’s Tau Vaccine Shows Promise for Alzheimer’s and Dementia Patients

AXON’s Tau Vaccine Shows Promise for Alzheimer’s and Dementia Patients
AXON Neuroscience announced that AADvac1, a vaccine against tau (a protein that accumulates and forms tangles inside neurons in diverse neurodegenerative diseases) showed therapeutic potential in Alzheimer's disease (AD) and frontotemporal dementia (FTD) in a Phase 1 study. The announcement was made by Matej Ondrus, MD, the company’s medical director, at Axon’s symposium, "Frontiers in diagnostics and therapy of human tauopathies," held at the 13th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD 2017) in Vienna, Austria. Intracellular tangles of tau are associated with neuronal loss and with severity of dementia. Immunotherapy using the AADvac1 vaccine aims to induce the patient’s immune system to produce specific antibodies against abnormal forms of tau, with the ultimate goal of protecting neurons from degeneration. The Phase 1 study (NCT01850238) revealed that the antibodies elicited by vaccination with AADvac1 could recognize pathological tau in brains from Alzheimer's patients. This response could prevent, at least partially, the progression of the disease. Furthermore, results from an 18-month follow-up study showed that similar responses were obtained in corticobasal degeneration and progressive supranuclear palsy, two other neurodegenerative diseases. These data strongly suggest that the antibodies produced by the AADvac1 vaccine target a common denominator in diverse diseases. "In this 96-week study, we demonstrated that the vaccine is safe and we can detect first signals in the therapeutic efficacy," Norbert Zilka, PhD, AXON’s chief science officer, s
Subscribe or to access all post and page content.